rejuvant life tabs

AgeX and UCI collaborate on neurological disorder

Latest articles

A single source for longevity nutrition data

Edamam co-founder talks bringing nutrition into the digital world and seeking funding for expansion in food as medicine. When it comes to food nutrition data,...

The Sheekey Science Show – Senotherapeutics

Senotherapeutics are therapeutics strategies that target cellular senescence. They can work by killing senescent cells (senolytics), inhibiting the proinflammatory secretory phenotype of senescent cells (senomorphics)...

Michael Greve commits €300m for rejuvenation start-ups

The founder of Forever Healthy has committed €300 million to advance rejuvenation biotech start-ups – plus exclusive insights from Michael Greve. Michael Greve, founder of...

Capsida Biotherapeutics emerges from stealth with $140m

Versant Ventures and Westlake Village BioPartners launch next-generation gene therapy company with $50m series A; AbbVie collaboration provides $90m for gene therapies for CNS...

Most read

New NAD+ boosting longevity supplement hits the market

Elevant Prime dietary supplement contains a “high purity” form of NMN that has completed safety and toxicology testing. New York based health and wellness brand...

David Sinclair to co-chair $200 million biotech SPAC

Christian Angermayer's Frontier Acquisition Corp. holds significant longevity interest with David Sinclair and Peter Attia as Co-Chairs of the Board. Frontier Acquisition Corporation, a special...

JUVICELL sets sights on lifespan and healthspan

Ten ingredients, one capsule. JUVICELL is on a mission to deliver an all-in-one longevity supplement. Far from just supplementing their diet to ensure an adequate...
Supplement report

Editor's picks

A single source for longevity nutrition data

Edamam co-founder talks bringing nutrition into the digital world and seeking funding for expansion in food as medicine. When it comes to food nutrition data,...

The Sheekey Science Show – Senotherapeutics

Senotherapeutics are therapeutics strategies that target cellular senescence. They can work by killing senescent cells (senolytics), inhibiting the proinflammatory secretory phenotype of senescent cells (senomorphics)...

Michael Greve commits €300m for rejuvenation start-ups

The founder of Forever Healthy has committed €300 million to advance rejuvenation biotech start-ups – plus exclusive insights from Michael Greve. Michael Greve, founder of...
Rejuvant

Research partnership announced on neural stem cell research program for Huntington’s disease and other conditions.

Hot on the heels of announcing a partnership with a mystery Japanese biopharma firm, Longevity-focused biotech firm, AgeX Therapeutics (NYSE American: AGE), today announced a research collaboration with the University of California, Irvine using AgeX’s PureStem technology to derive neural stem cells, with the goal of developing cellular therapies to treat neurological disorders and diseases.

The collaboration’s initial focus will be on Huntington’s disease, while other potential targets may include Parkinson’s, Alzheimer’s and stroke. Initial R&D work, expected to take approximately one year, will be conducted in the UCI laboratory of Professor Leslie Thompson, a leading researcher in the field of Huntington’s disease and other neurological disorders.

The collaboration combines clinical validation with commercial opportunity, with an option for AgeX Therapeutics to organise a company to be jointly owned with Professor Thompson and other researchers to pursue clinical development and commercialisation of cell therapies derived using licensed inventions arising from the research programme.


“This is an example of the kind of collaboration we will be seeking under our newly-unveiled collaboration and licensing strategy…”


 

“This is an example of the kind of collaboration we will be seeking under our newly-unveiled collaboration and licensing strategy,” said Greg Bailey, MD, Chairman of AgeX. “In this instance, we will be collaborating with a world leader in their field on a research project which is close to the clinic.”

Elevant

AgeX Therapeutics
Greg Bailey, Chairman, AgeX

The primary goal of the research is to develop a robust method of deriving neural stem cells from pluripotent stem cells in sufficient quantity and with sufficient purity and identity for use in cell-based therapy. Professor Thompson’s laboratory has already accumulated safety and efficacy animal data that may support an IND submission to the FDA as early as 2021 for the commencement of clinical trials to treat Huntington’s disease.

Elevant

“We look forward to utilizing AgeX’s cell derivation and manufacturing PureStem technology, with its many potential advantages, including industrial scalable manufacturing, lower cost of goods, and clonal cells with high purity and identity,” said Professor Thompson. “Our goal is to have an improved neural stem cell production method ready within a year to move into clinical development.”


“Our goal is to have an improved neural stem cell production method ready within a year to move into clinical development…”


 

“We are delighted to start this exciting collaboration with Professor Thompson, who has worked tirelessly over her career to develop a neural stem cell product candidate for Huntington’s disease and who has already generated preclinical animal data that may support the initiation of clinical studies,” said Dr Nafees Malik, Chief Operating Officer of AgeX. “Moreover, we are very excited to be entering the field of neurology, which has huge clinical and commercial potential. Neural stem cells may be very useful in other neurological disorders that are common in aging demographics, such as Parkinson’s, Alzheimer’s and stroke.”

Image credit: David Tonelson / Shutterstock
Danny Sullivan
Contributing Editor Danny has worked in technology communications for more than 15 years, spanning Europe and North America. From bionics and lasers to software and pharmaceuticals – and everything in between – he’s covered it all. Danny has wide experience of technology publishing and technical writing and has specific interest in the transfer from idea to market.
Rejuvant

Most popular

New NAD+ boosting longevity supplement hits the market

Elevant Prime dietary supplement contains a “high purity” form of NMN that has completed safety and toxicology testing. New York based health and wellness brand...

David Sinclair to co-chair $200 million biotech SPAC

Christian Angermayer's Frontier Acquisition Corp. holds significant longevity interest with David Sinclair and Peter Attia as Co-Chairs of the Board. Frontier Acquisition Corporation, a special...

JUVICELL sets sights on lifespan and healthspan

Ten ingredients, one capsule. JUVICELL is on a mission to deliver an all-in-one longevity supplement. Far from just supplementing their diet to ensure an adequate...

Is nicotinamide riboside a safe and effective way to combat aging?

ChromaDex executive highlights the importance of clinical studies to prove the benefits of NAD+ boosting compound. ChromaDex is the company behind the popular healthy aging...
Supplement report

Related articles

Building a longevity biotech from scratch

Alchemab exec talks company creation and how antibody therapeutics may play a role in longevity biotech. Last week, we covered Alchemab Therapeutics’ $82 million Series...

Cellino: longevity powered by AI, stem cells & democracy

From a serendipitous meeting of minds to laser-enabled precision, Cellino is leveraging AI and pluripotent stem cells for longevity. We speak to CEO and...

Does the placenta hold the key to human longevity?

Part 2 of our exclusive interview with Celularity founder Dr Robert Hariri discusses the potential of the placenta in regenerative medicine and human longevity. The...

Paving the way to future organ factories

Extracellular matrix obtained by controlled decellularisation is used to reconstruct the liver with human-like characteristics, paving the way for transplantable livers. Researchers at the Human...

The placenta: a limitless source of stem cells?

Part 1 of our exclusive interview with Celularity founder Dr Robert Hariri covers the discovery of placental pluripotent stem cells and the journey towards...
Supps report ad middle