CalmiGo

Big Brother approach to accelerate preclinical studies

Latest articles

The Sheekey Science Show – Aging Clocks

Aging clocks - how to measure biological age. I hope you have some time on you hands as today we will talk all about aging...

Berberine could be longevity’s “best-kept secret”

From tackling senescence to lowering blood sugar, berberine is the supplement with a host of tricks up its sleeves. Berberine is a bioactive compound found...

Over a third of Generation X have multiple health problems

More than one in three British adults are suffering from two or more chronic health conditions in middle age, such as recurrent back problems,...

Forget the arms race – it’s time for a longevity race

Professor Andrew Scott outlines how society needs to change in order to capitalise on multi-trillion dollar longevity dividend. Last week, we brought you the views...

Most read

New NAD+ boosting longevity supplement hits the market

Elevant Prime dietary supplement contains a “high purity” form of NMN that has completed safety and toxicology testing. New York based health and wellness brand...

David Sinclair to co-chair $200 million biotech SPAC

Christian Angermayer's Frontier Acquisition Corp. holds significant longevity interest with David Sinclair and Peter Attia as Co-Chairs of the Board. Frontier Acquisition Corporation, a special...

Tree of Longevity – understanding how supplements work

Pathways? Hallmarks? Biomarkers? Understanding the longevity supplements lingo can help you make better choices for your healthspan. Longevity supplements differ from other 'generic supplements' as...
Seno

Editor's picks

The Sheekey Science Show – Aging Clocks

Aging clocks - how to measure biological age. I hope you have some time on you hands as today we will talk all about aging...

Berberine could be longevity’s “best-kept secret”

From tackling senescence to lowering blood sugar, berberine is the supplement with a host of tricks up its sleeves. Berberine is a bioactive compound found...

Over a third of Generation X have multiple health problems

More than one in three British adults are suffering from two or more chronic health conditions in middle age, such as recurrent back problems,...
CalmiGo

Click the globe for translations.

Tracked.bio develops AI computer vision system that tracks flies and mice to reduce man-hours and increase data collected in Longevity studies.

A Danish start-up aims to accelerate and enhance the data collection process during preclinical Longevity studies on flies and mice. Backed by Insilico Medicine’s Alex Zhavoronkov, University of Copenhagen spin-out Tracked.bio is developing what it calls a “fully automated phenotyping and identification system for model organisms.”

Longevity.Technology: While much of the focus of Longevity drug development is on reaching clinical trials in humans, preclinical studies in animal models are absolutely critical to Longevity research. While they are a vital step on the road to getting therapies into the clinic, animal studies are time- and effort-intensive, and any opportunity to streamline this area could have significant benefits for the industry. We caught up with Tracked.bio co-founder and CEO Michael Petr to find out more.

Petr originally trained as a biomedical engineer but became increasingly interested in the science of aging, leading to a fellowship at the National Institute of Aging at NIH in Baltimore, and a PhD at the University of Copenhagen.

Tracked.bio co-founder and CEO Michael Petr

“During my PhD, I started working with different animal models, which are very common in ageing research, like fruit flies and mice,” says Petr. “It’s very laborious work, and so we wanted to automate this work in the lab, and that was the inspiration behind Tracked.bio – trying to automate a lot of the manual counting and analysis with software.”

A lot of Petr’s lab work involved looking at lifespan and testing different interventions on fruit flies, for example.

“Part of the hands-on nature of this research is going in and manually checking visually how many are alive, or how well they’re doing,” he says. “This takes several months, so any way to standardise it was interesting to us. So we started from that need to basically standard standardise our studies and also speed them up in some ways.”

 


 

“By using our system, we can now look at both lifespan and frailty hands-off …”

 

 


 

 

Petr and his co-founders put their heads together on the problem and developed a deep learning computer vision system based on convolutional neural networks. Using a combination of AI and 24-7 monitoring, Tracked.bio is designed to help standardise and automate the quantification of studies in model organisms.

“By using our system, we can now look at both lifespan and frailty hands-off, and a big driver was to do this analysis with just our system alone,” says Petr. “This performs the work of two to three people having to manually do these checks. And we can also extract much more information – we can calculate things that couldn’t be manually picked up – for example, the system can predict the age of a fly from an image.”

 

 


 

 

“ … we’re saving several hours of our own people’s time – probably five to 10 hours per week …”

 

 


 

 

At this point, Tracked.bio has developed a working prototype, and is using the system on Petr’s own projects and collaborative studies, saving considerable man hours, while increasing the output and the amount of data collected.

“At least in our own hands, we’re saving several hours of our own people’s time – probably five to 10 hours per week, just in our own studies alone,” say Petr. “And this is just a fraction of the studies that we’re doing. We’re planning to expand to larger studies with mice soon, and we expect that the order of magnitude of time-saving with the mouse studies will be even higher.”

In the short-term, Tracked.bio is working on “finishing up” some of the academic aspects of proving the technology, and will then seek to commercialise the product.

“We’re talking with potential areas of funding and incubators, but it’s still very early days for us,” says Petr. “Pre-seed fundraising is definitely something we’re looking at to help us finalise the product, but also towards some of the in-house studies – specifically the mouse studies.”

Image courtesy of Michael Petr
Danny Sullivan
Contributing Editor Danny has worked in technology communications for more than 15 years, spanning Europe and North America. From bionics and lasers to software and pharmaceuticals – and everything in between – he’s covered it all. Danny has wide experience of technology publishing and technical writing and has specific interest in the transfer from idea to market.
CalmiGo

Most popular

New NAD+ boosting longevity supplement hits the market

Elevant Prime dietary supplement contains a “high purity” form of NMN that has completed safety and toxicology testing. New York based health and wellness brand...

David Sinclair to co-chair $200 million biotech SPAC

Christian Angermayer's Frontier Acquisition Corp. holds significant longevity interest with David Sinclair and Peter Attia as Co-Chairs of the Board. Frontier Acquisition Corporation, a special...

Tree of Longevity – understanding how supplements work

Pathways? Hallmarks? Biomarkers? Understanding the longevity supplements lingo can help you make better choices for your healthspan. Longevity supplements differ from other 'generic supplements' as...

Spermidine: the mind-enhancing supplement

Scientists are finding that a high intake of dietary spermidine could slow down (or reverse) the brain aging process. Memory loss and slower brain function...
Seno

Related articles

A pawsitive take in Alzheimer’s disease modelling

As purr-plexing as it may seem, cats may provide key answers in the study of dementia and Alzheimer’s disease. As we get older, our brain...

Reader Poll: just what does your future look like?

Your future is getting inexorably nearer – but will that be in high-tech comfort in your own home, down the road in a state-of-the-art...

Gerostate passes crowdfunding goal for antiaging drug platform

Longevitytech.fund joins investment round as Buck Institute start-up continues crowdfunding campaign to move antiaging drug candidates into mammalian studies. With around two weeks still remaining...

3D structure of all proteins? You’ll have to Google that!

By unlocking and sharing the secrets of protein structures, DeepMind could supercharge drug discovery – this could be one of the biggest contributions of...

Scientists reverse age-related memory loss in mice

Scientists have successfully reversed age-related memory loss in mice – discovery could lead to the development of treatments to prevent memory loss in people...
Seno