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Mitochondria

Joined-up thinking and the hallmarks of aging

A recent article provides an integrative view of the hallmarks of aging and the extensive network linking them: time to join-up our thinking? Mitochondria are...

Calcium and ROS crosstalk: a key to extending healthspan?

Mounting evidence shows an important role for calcium and ROS interplay in fine-tuning cellular signalling and physiological responses, thereby regulating aging and age-related disorders....

GDF15 protects from age‐related metabolic phenotypes

A recent study shows an important role for GDF15 in preventing aging-induced metabolic phenotypes by modulating systemic inflammatory responses in humans and mice. Dysfunction of...

New CRISPR-free gene-editing tool exploits bacterial warfare

New tool uses an interbacterial toxin to achieve precise mitochondrial gene editing without CRISPR side-effects. Mitochondria – often called the "powerhouse" of the cell –...

Longevity investment: Apollo aims for the moon

Co-founder of Longevity-focused investment firm shows you can target aging AND appeal to biotech investors. Founded in 2016, Berlin and Boston-based Apollo already boasts an...

Off-patent protein could be a key to Longevity

Could off-patent humanin actually have a bigger part to play in Longevity and healthy aging? They say that good things come in small packages and a...

Metformin boost for inflammaging research

Researchers use metformin to repair broken cell machinery and drastically lower dangerous inflammation. Inflammaging is one of the latest Longevity buzzwords; it has been around...

Two novel anti-aging targets identified

A recent Chinese study has identified two novel anti-aging targets that accelerate aging by suppressing the expression of genes involved in mitochondrial function maintenance: promoting...

Pathway to Longevity: get rid of zombie cells

Understanding the trigger for cellular senescence could help to forge new treatments for Longevity, stopping aging before it's started. Cellular senescence is a double-edged sword;...

Targeting mitochondria to fight aging

New study shows that two experimental drugs can reverse age-related cognitive impairment and potentially treat Alzheimer's disease, by restoring mitochondrial function in the aging...

Next generation of senescence research

Teenage founder of Canadian start-up Biotein hunts a universal phenotype for senescent cells. Nina Khera (pictured above, first left) became interested in the challenge of...

Elysium announces epigenetic aging clinical trial

Elysium Health is to study correlations between epigenetic aging and amounts of NAD+ and other biomarkers in a new clinical trial. Fresh on the back...

Dr Nir Barzilai: Creating a template for all aging trials

There are few voices in Longevity research as distinctive as Dr Nir Barzilai’s. Brimming with jokes and references, his sentences digress and then return to...

Taking life-extending drug Rapamycin to the next level

Life extension studies fly the flag for Rapamycin – a clever drug with humble origins – now a US research team is taking matters...

Metformin could limit the health benefits of exercise

Report finds that anti-diabetic drug metformin could make exercise less effective at improving health but aging researchers remain upbeat. Metformin has been, for a long...

Parkinson’s charity backs new biotech NRG Therapeutics

Parkinson’s UK charity strikes a £1 million deal partnership with NRG Therapeutics for developing drugs aimed at mitochondria. The UK’s leading charity for this disease...

Heathspan boost as researchers find link between mitochondria and osteoporosis

Scientists find promising pathway that links mitochondrial damage from smoking and drinking to osteoporosis. The risk factors of osteoporosis, an age-related disease, have long been...
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