Senolytic drugs

Re-engineered immune cells are the life and soul of the CAR T

Chimeric cells prove effective senolytic agents in targeting aging. CAR T cells are being deployed against diseases caused by senescence with the hope that they...

“Avoid the use of DQ as a senolytic therapy”

Forever Healthy Foundation issues risk-benefit analysis on dasatinib + quercetin as a senolytic. The Forever Healthy Foundation today published its latest risk-benefit analysis, which explores...

Classifying aging as a disease – it’s all about the ‘how’

The hurdle of classifying aging as a disease, rather than an inevitability, has started to be overcome. Now Alex Zhavoronkov is pushing for us...

Longevity2020: Day 5 Recap

On Friday, the Longevity2020 online conference drew to a close, and the final day explored what people can be doing today to address their...

Longevity2020: Day 2 recap

Yesterday at Longevity2020 was all about rejuvenation therapies, bringing together some of the world’s leading luminaries in the fight against aging. Things kicked off with...

Oisín on aging as a disease and raising $5m seed

Co-founder Gary Hudson talks cell senescence, trials, spin-outs and the dilemma of treating age as a disease. Every entrepreneur in Longevity has a different story...

Pathway to Longevity: get rid of zombie cells

Understanding the trigger for cellular senescence could help to forge new treatments for Longevity, stopping aging before it's started. Cellular senescence is a double-edged sword;...

Exclusive interview: A new generation of senolytic

When is a drug not a drug? When it's a NaNot. Interesting new technology that's already on its way through FDA and targeting $40m Series...

Senolytic breakthrough brings Longevity one giant leap closer

Mayo clinic researchers demonstrate senolytic drugs clearing senescent cells in humans for the first time. In a landmark trial, researchers from the Mayo clinic have...

Professor Lynne Cox talks senescence

Calling for better alignment between academia, spin outs and big pharma - we talk senolytic drug development with a key opinion leader Lynne Cox is...

“And it turns out I was right” Aubrey de Grey

Exclusive interview: Aubrey de Grey meets Longevity.Technology “You shall not cut the hair on the sides of your heads, neither shall you clip off the...

Could senolytics be holding the cure for Alzheimer’s?

For years, scientists have assumed amyloid plaques caused neurodegenerative conditions like Alzheimer’s disease. Now the consensus appears to be shifting, and the implications for...

HIV drug expands into treatment of Alzheimer’s and other age-related diseases

Breakthrough by Brown University researcher on HIV significantly reduces age-related inflammation in old mice and senescent human cells. In a discovery that was described by...

Senolytic knee injection for osteoarthritis could unlock Longevity

Osteoarthritis causes crippling pain for millions, but what if relieving that pain also unlocked the key to Longevity? Approximately 350 million people worldwide suffer from...

Latest articles

Evidence for tenth hallmark of aging increases with new paper

Is ten the new nine? Additional research adds weight to the argument that extracellular matrix stiffening should be considered the tenth hallmark of aging. Since...

Help us help you: Longevity biotech survey

A new survey on translational processes and hurdles to clinical trials in Longevity biotech. We're working with two MDs: Oliver Zolman and Jian Fransen, on...

First Longevity announces first investors for current round

Some news of our own: European VC fund and a Longevity innovator participate in the First Longevity funding round. Last week we announced that Tom...

GDF15 protects from age‐related metabolic phenotypes

A recent study shows an important role for GDF15 in preventing aging-induced metabolic phenotypes by modulating systemic inflammatory responses in humans and mice. Dysfunction of...