rejuvant life tabs

Does the placenta hold the key to human longevity?

Latest articles

A single source for longevity nutrition data

Edamam co-founder talks bringing nutrition into the digital world and seeking funding for expansion in food as medicine. When it comes to food nutrition data,...

The Sheekey Science Show – Senotherapeutics

Senotherapeutics are therapeutics strategies that target cellular senescence. They can work by killing senescent cells (senolytics), inhibiting the proinflammatory secretory phenotype of senescent cells (senomorphics)...

Michael Greve commits €300m for rejuvenation start-ups

The founder of Forever Healthy has committed €300 million to advance rejuvenation biotech start-ups – plus exclusive insights from Michael Greve. Michael Greve, founder of...

Capsida Biotherapeutics emerges from stealth with $140m

Versant Ventures and Westlake Village BioPartners launch next-generation gene therapy company with $50m series A; AbbVie collaboration provides $90m for gene therapies for CNS...

Most read

New NAD+ boosting longevity supplement hits the market

Elevant Prime dietary supplement contains a “high purity” form of NMN that has completed safety and toxicology testing. New York based health and wellness brand...

David Sinclair to co-chair $200 million biotech SPAC

Christian Angermayer's Frontier Acquisition Corp. holds significant longevity interest with David Sinclair and Peter Attia as Co-Chairs of the Board. Frontier Acquisition Corporation, a special...

JUVICELL sets sights on lifespan and healthspan

Ten ingredients, one capsule. JUVICELL is on a mission to deliver an all-in-one longevity supplement. Far from just supplementing their diet to ensure an adequate...
Supplement report

Editor's picks

A single source for longevity nutrition data

Edamam co-founder talks bringing nutrition into the digital world and seeking funding for expansion in food as medicine. When it comes to food nutrition data,...

The Sheekey Science Show – Senotherapeutics

Senotherapeutics are therapeutics strategies that target cellular senescence. They can work by killing senescent cells (senolytics), inhibiting the proinflammatory secretory phenotype of senescent cells (senomorphics)...

Michael Greve commits €300m for rejuvenation start-ups

The founder of Forever Healthy has committed €300 million to advance rejuvenation biotech start-ups – plus exclusive insights from Michael Greve. Michael Greve, founder of...
Rejuvant

Part 2 of our exclusive interview with Celularity founder Dr Robert Hariri discusses the potential of the placenta in regenerative medicine and human longevity.

The first part of our interview with Dr Hariri covered the discovery of pluripotent stem cells in the placenta and the journey to the formation of Celularity to commercialise that discovery. Today, the company is in multiple clinical trials of cell therapies for cancers and tumours, with therapies for degenerative disease also under development.

Longevity.Technology: As Hariri is also a founder of genomic health intelligence company Human Longevity Inc, we were keen to get his perspective on how he believes his work at Celularity can play a role in age-related disease and regenerative medicine.

Robert Hariri
Celularity founder and CEO, Dr Robert J Hariri

Rather than focus on a numerical marker like lifespan, Hariri believes that extension of healthspan is a much more relevant aspect of human longevity.

“In my mind, the real objective is the preservation of human performance,” he says. “And the degenerative disease application of cellular medicine is not only important to me, but it is a very lucrative opportunity in health care.”

Stem cells “fundamental” to regenerative medicine

Hariri believes extending lifespan only makes sense if, in parallel, you can preserve three things: high-performance mobility, high-performance cognitive function and youthful aesthetics.

“I am completely convinced that stem cells are a fundamental part of our ability to respond to illness and disease, but most importantly, respond to the effects of aging,” he says. “Everything I’ve learned in the last 25 years has supported that. And I am absolutely convinced that the most obvious way to do that is to simply restore the population of stem cells in your body that are naturally driving the remodelling, renewal and renovation of your body, year after year after year.

“Your regenerative engine, which keeps you young and healthy, is driven by a reservoir of stem cells that you’ve been carrying along with you since birth. But that reservoir gets depleted, both quantitatively and qualitatively over time. We have clear biological evidence… people who stay really healthy in old age just happened to have healthier, higher integrity stem cell populations.”

Aging and the immune system

The potential for using stem cells to repair damage to specific areas, like the cartilage in a joint, for example, is well understood. But Hariri believes there is a broader opportunity for the technology to play a role in addressing the irreversible degenerative changes that happen to an aging individual.

“Your ability to evade causes of premature death can all be linked back to the integrity and the efficiency and the health of your immune system,” he says. “Over time, inflammation will destroy every organ and tissue in the body.”

Elevant

Celularity
At work in the Celularity lab

Hariri describes Celularity as “a company that has mastered the recovery of the leftovers of full-term healthy pregnancies, and then created a manufacturing system to isolate the cellular products, as well as the biological materials from that organ, and turn them into useful medicines.”

“And every one of them can play a role in either arresting or reversing those degenerative processes – either by affecting the immune system, or by supporting healthy functional repair or regeneration of the organs and tissues after a disease or an injury.”

On a 50-year mission

So where does Hariri see Celularity heading in the future?

“I’m really optimistic and hopeful that our platform, which is all placental, will be seen as the leading place to find cells for therapeutics, and that these cells are safe and effective,” he says. “And then, once we show that they’re safe and effective in indications, each indication builds upon itself. So we can chase the mainstream applications, like age-related frailty and things like that.”

“We’ve been doing this for 20 years, we have a incredibly rich intellectual property portfolio, we’ve got one of the longest, if not the longest, experience in manufacturing cellular products. And so when you combine all those things, we’re in a very powerful position to kind of lead the next evolution of cellular medicine, where everything is off-the-shelf.

Cellular medicine is, Hariri believes, a resource that deserves enormous attention, and that Celularity’s mission is to help bring it that attention, while demonstrating its safety and efficacy in ways that are relevant to the clinical community and to the regulatory community.

Elevant

“When I started, I said this was a 50 year mission, and we’re in year 22 right now, so there’s a lot more to be done,” he says.

Images courtesy of Celularity

 

 

 

 

Comment on this article

Danny Sullivan
Contributing Editor Danny has worked in technology communications for more than 15 years, spanning Europe and North America. From bionics and lasers to software and pharmaceuticals – and everything in between – he’s covered it all. Danny has wide experience of technology publishing and technical writing and has specific interest in the transfer from idea to market.
Rejuvant

Most popular

New NAD+ boosting longevity supplement hits the market

Elevant Prime dietary supplement contains a “high purity” form of NMN that has completed safety and toxicology testing. New York based health and wellness brand...

David Sinclair to co-chair $200 million biotech SPAC

Christian Angermayer's Frontier Acquisition Corp. holds significant longevity interest with David Sinclair and Peter Attia as Co-Chairs of the Board. Frontier Acquisition Corporation, a special...

JUVICELL sets sights on lifespan and healthspan

Ten ingredients, one capsule. JUVICELL is on a mission to deliver an all-in-one longevity supplement. Far from just supplementing their diet to ensure an adequate...

Is nicotinamide riboside a safe and effective way to combat aging?

ChromaDex executive highlights the importance of clinical studies to prove the benefits of NAD+ boosting compound. ChromaDex is the company behind the popular healthy aging...
Supplement report

Related articles

Building a longevity biotech from scratch

Alchemab exec talks company creation and how antibody therapeutics may play a role in longevity biotech. Last week, we covered Alchemab Therapeutics’ $82 million Series...

Cellino: longevity powered by AI, stem cells & democracy

From a serendipitous meeting of minds to laser-enabled precision, Cellino is leveraging AI and pluripotent stem cells for longevity. We speak to CEO and...

Paving the way to future organ factories

Extracellular matrix obtained by controlled decellularisation is used to reconstruct the liver with human-like characteristics, paving the way for transplantable livers. Researchers at the Human...

The placenta: a limitless source of stem cells?

Part 1 of our exclusive interview with Celularity founder Dr Robert Hariri covers the discovery of placental pluripotent stem cells and the journey towards...

Insulin – predictor of longevity

Body weight stands for far more than simple aesthetics – it is key for longevity. From a single cell to a fully functioning human adult,...
Supps report ad middle