New supplement combines daily immunomodulatory supplement with an intermittent senolytic complex to combat immune aging.
New York-based life sciences company Elysium Health™ has announced the launch of FORMAT™, a product designed to provide advanced immune support; FORMAT has a formulation based on research conducted at the Mayo Clinic by James Kirkland, MD, PhD, Elysium Scientific Advisory Board member and director of the Robert and Arlene Kogod Center on Aging at the Mayo Clinic. The Mayo Clinic has a financial interest in Elysium Health through its licensing arm, Mayo Clinic Ventures.
Longevity.Technology: FORMAT pairs a daily immunomodulatory supplement with an intermittent senolytic complex with the aim of combatting the effects of immune aging and providing complete immune support. Our immune system deteriorates as we age and this process – immunosenescence and the changes in the immune system associated with age – has become a focus for research, especially teasing out the nuances of its vicious cycle with inflammaging. Human life expectancy is increasing, but evolution has not yet caught up with regards to our immune system, meaning the older you get, the more susceptible you are to cancers and infection. Bolstering our immune system makes sense, especially in a straightforward daily FORMAT.
Format’s daily immunomodulatory supplement combines micronutrients, which are critical at every stage of the immune response, with a Free Radical Protection Complex containing antioxidants including sulforaphane and elderberry and an Autophagy Activation Complex that includes bioavailable green tea phytosomes and chalcone flavonoids.
The Senolytic Complex contains a blend of quercetin and fisetin to help the body manage senescent cells, which supports healthy immune function and combats immunosenescence. Dr Kirkland advises on studying the potential uses of natural products for alleviating age-related dysfunction or disorders and about assays for tracking fundamental aging processes.
“At Elysium Health, we develop novel products with the world’s best scientists and institutions at the forefront of aging research to help people lead healthier lives,” said Elysium Health CEO Eric Marcotulli. “As a company focused on aging research, addressing age-related decline in immune function has been part of our product pipeline for several years. Format is the first and only product to address immune aging by uniquely combining a daily immune supplement to support healthy immune function with an intermittent senolytic complex to help the body manage senescent cells and combat inflammaging and immunosenescence.”
Immunosenescence, which broadly describes age-related decline of the immune system, is a natural part of the aging process that occurs universally, even in healthy adults. One potential cause of this age-related decline is the accumulation of senescent cells – cells that stop dividing but remain metabolically active. The accumulation of senescent cells places a burden on the immune system, contributes to inflammation, and has been associated with numerous health concerns.
Recent research has also shown that senescent immune cells have the ability to accelerate systemic aging. In people of any age, the immune system can be quickly compromised as a result of various lifestyle factors, including lack of sleep, a diet poor in fruits and vegetables and high in fat, anxiety and chronic stress, smoking and excessive alcohol consumption; according to the National Institutes of Health, drinking to excess on even a single occasion slows your body’s ability to ward off infections for up to 24 hours.
“Format is unique in combining a daily immunomodulatory cocktail with intermittent, proven senolytic compounds to clear senescent cells,” said Elysium Health chief scientist and director of the Glenn Center for Biology of Aging Research at MIT Dr Leonard Guarente. “It is a safe way to provide multi-pronged immune support that is not available in any other health supplement. Indeed, a recent preclinical study by Yousefzadeh et al. published in Nature demonstrated that senescent hematopoietic cells can play a critical role in aging and health decline.”
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