First human AI-powered psychological aging clock published

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Deep Longevity publishes the first set of psychomarkers of aging – using deep learning to link psychological aging with mortality risk.

Deep Longevity, which was this week fully acquired by Regent Pacific, has published the first set of psychomarkers of aging. These have been developed using deep learning to track psychological changes and assess the effectiveness of interventions, life events, and external events. The new PsychoAge and SubjAge aging clocks were linked to mortality risk.

Longevity.Technology: We’ve written much about biomarkers, biological molecules, genes, or characteristics by which a particular pathological or physiological process, condition or disease – usually aging for us – can be identified. Collect biomarker data, leverage powerful AI tools like machine learning, and you’ve got yourself an aging clock. Aging clocks that can accurately quantify the human aging process using a range of biological data types are among some of the most important recent advances in the field of Longevity research, and now there is a new twist, psychomarkers.

Deep Longevity, which develops AI to track human aging and extend productive Longevity, has released the first AI-powered psychological aging clocks to analyse and interpret psychosocial factors in the context of aging. Deep Longevity researchers, joined by the visionary physician, engineer, and entrepreneur, the founder of the XPRIZE Foundation and Singularity University, Dr Peter Diamandis, published their study titled “PsychoAge and SubjAge: Development of Deep Markers of Psychological and Subjective Age Using Artificial Intelligence” in Aging.

Like other species following the classical evolutionary paradigm, humans are born, develop, reproduce, take care of their young, and then gradually decline and die. However, humans are conscious intelligent species and change their behaviour, priorities, beliefs, and attitudes, during life. Prior works on Socioemotional Selectivity Theory (SST) demonstrated that human life horizons can be manipulated and affect behaviour. To better understand the features that affect psychological age, and perceived age, and the mind-body connection in the context of aging, scientists at Deep Longevity decided to apply their skills in the development of deep biomarkers of aging to human psychology.

 


 

“For the first time, AI can predict human psychological and subjective age and help identify the possible interventions that can be applied in order to help people feel and behave younger …”

 


 

Despite massive progress in aging clock technology, such as Deep Longevity’s DNA methylation aging clock which was released last month, the psychological aspect of aging has yet to be harnessed. However, the new study on deep psychomarkers of aging should substantially accelerate progress and understanding in the psychology of aging.

The recently published study aims to fill this gap by demonstrating two AI-based age predictors: PsychoAge (which predicts chronological age) and SubjAge (which describes personal aging rate perception). These models were trained on a collection of >10,000 questionnaires completed by people aged 25-75 years as a part of the MacArthur Foundation’s “Midlife in the United States (MIDUS)” study. The models presented in the publication were reworked into 15-question long surveys available at Young.AI to enable people to find out estimates of their psychological and subjective age.

 


 

The authors of the study verified the SubjAge on large independent datasets to discover that higher SubjAge is very predictive of all-cause mortality.

 


 

The authors of the study verified the SubjAge on large independent datasets to discover that higher SubjAge is very predictive of all-cause mortality. More specifically, a person whose SubjAge is five years greater than the subjective age he or she reported is twice as likely to die as a person with normal age perception [1].

The authors also point out how SubjAge can be manipulated therapeutically to make patients feel younger and thus reduce their mortality risk. For example, developing openness to new experiences can reduce SubjAge prediction by seven years. Keeping the bar high, being productive and not backing away from difficult-to-reach goals will take another four years off of a person’s psychological aging clock.

“For the first time, AI can predict human psychological and subjective age and help identify the possible interventions that can be applied in order to help people feel and behave younger” said Alex Zhavoronkov, PhD, founder and CEO of Deep Longevity and co-author of the study. “One’s mindset may determine the decisions that ultimately affect their overall health. By identifying the psychosocial variables that underpin particular mindsets and behaviours, deep psychological clocks can serve as a powerful tool in promoting personal improvement, mental health, wellness, and a wide range of other health and therapeutic applications.”

In follow-up studies of psychological aging, Deep Longevity plans to explore differences in the perception of aging between men and women, examine psychosocial markers connected to mental health, and build an integrated model of mental-physical health crosstalk.

[1] https://www.aging-us.com/article/202344/text

Eleanor Garth
Deputy Editor Now a science and medicine journalist, Eleanor worked as a consultant for university spin-out companies and provided research support at Imperial College London and various London hospitals in a former life.

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