rejuvant life tabs

“Human-on-a-Chip” OOC to revolutionise preclinical

Latest articles

Paving the way to future organ factories

Extracellular matrix obtained by controlled decellularisation is used to reconstruct the liver with human-like characteristics, paving the way for transplantable livers. Researchers at the Human...

Charles Brenner: the journey from NR to Tru Niagen

Dr Charles Brenner, the developer of the intellectual property behind ChromaDex's Tru Niagen, on all things metabolism, NAD and NR clinical trials. Longevity.Technology: Following the...

Longevity investment firm announces acceleration programme

Call for future founders: longevity investment fund LongeVC announces in-house acceleration programme. LongeVC – a longevity investment group backed by an advisory board with solid...

The placenta: a limitless source of stem cells?

Part 1 of our exclusive interview with Celularity founder Dr Robert Hariri covers the discovery of placental pluripotent stem cells and the journey towards...

Most read

New NAD+ boosting longevity supplement hits the market

Elevant Prime dietary supplement contains a “high purity” form of NMN that has completed safety and toxicology testing. New York based health and wellness brand...

David Sinclair to co-chair $200 million biotech SPAC

Christian Angermayer's Frontier Acquisition Corp. holds significant longevity interest with David Sinclair and Peter Attia as Co-Chairs of the Board. Frontier Acquisition Corporation, a special...

JUVICELL sets sights on lifespan and healthspan

Ten ingredients, one capsule. JUVICELL is on a mission to deliver an all-in-one longevity supplement. Far from just supplementing their diet to ensure an adequate...
Supplement report

Editor's picks

Paving the way to future organ factories

Extracellular matrix obtained by controlled decellularisation is used to reconstruct the liver with human-like characteristics, paving the way for transplantable livers. Researchers at the Human...

Charles Brenner: the journey from NR to Tru Niagen

Dr Charles Brenner, the developer of the intellectual property behind ChromaDex's Tru Niagen, on all things metabolism, NAD and NR clinical trials. Longevity.Technology: Following the...

Longevity investment firm announces acceleration programme

Call for future founders: longevity investment fund LongeVC announces in-house acceleration programme. LongeVC – a longevity investment group backed by an advisory board with solid...
Rejuvant

New system of linked mini-organs heralds a new era of comprehensive drug testing that is faster and more efficient than anything seen before. OOC techniques combined with AI will accelerate discovery.

Preclinical trials can be slow and costly; identifying and excluding toxic effects, finalising administration routes and calculating concentrations all take time and refinement. Enter organs-on-a-chip (OOC).

Longevity.Technology: Drugs need human trials, but the drugs need to be safe enough to test and predicting the way a drug will effect a human body cannot be done with enough accuracy from either animal or standard in vitro testing. Add in the fact that 60-90% of the drugs that are successful in mice trials fail in humans, and there is a pressing need to work smarter, not harder.

Over the last ten years, various organs on various chips have been developed, however, potential drugs are tested in sequence, meaning the process is slow. Now a team from Tel Aviv and Harvard Universities has managed to connect various simulated organs and has shown that they can react to drugs just as human organs would in a clinical trial. Organs included so far include intestine, liver, kidney, heart, lung, skin, blood-brain barrier and the brain.

OOC

Tel Aviv’s Dr Ben Maoz said: “We created a unique machine that connects between the nine organs, the brain, the lung, the bone marrow, and others, like a ‘Lego,’ to create a mini ‘Human-on-a Chip’ [1].”

Co-author Professor Donald Ingber, founding director of Harvard University’s Wyss Institute, said: “To solve this massive preclinical bottleneck problem, we need to become much more effective at setting the stage for drugs that are truly promising and rule out others that for various reasons are likely to fail in people [2].”


“This is what we love to do … make science fiction into science fact …”


 

“This is what we love to do at the Wyss Institute: make science fiction into science fact,” Professor Ingber added. “We hope our demonstration that this level of biomimicry is possible using Organ Chip technology will garner even greater interest from the pharmaceutical industry so that animal testing can be progressively reduced over time [3].”

Elevant

First the research team developed the “Interrogator”; this is a robotic liquid transfer device that links the individual organ chips and mimics the flow of blood around the body and between the organs in the body. The organ chips have two parallel hollow channels; one is lined with specific organ cells, while the other is lined with vascular endothelial cells that function like a blood vessel. A membrane in between enables the two parts to communicate with each other, exchanging molecules.

OCC explained

Next the team linked the Interrogator with a novel computational model to a series of linked organ chips to test nicotine and cisplatin with successful results. Professor Ingber said. “The modularity of our approach and availability of multiple validated Organ Chips for a variety of tissues for other human Body-on-Chip approaches now allows us to develop strategies to make realistic predictions about the pharmacology of drugs much more broadly. Its future use could greatly increase the success rates of Phase I clinical trials [4].”

Dr Maoz added: “We hope that this platform will enable us to bridge the gap on current limitations in drug development by providing a practical, reliable, relevant system for testing drugs for human use [5].”

Elevant

In terms of speeding drug development, organ-on-chip (OOC) technology is a key Longevity sector – combined with AI, OOC will dramatically accelerate the drug discovery process. We have covered BIOFABICS’ growth in this area, as well as previous work by the Wyss Institute on using OOC to overcome the tricky Blood-Brain-Barrier.

[1] https://bit.ly/2GNAqKy
[2] https://www.sciencedaily.com/releases/2020/01/200127134724.htm
[3] https://bit.ly/36Y7z0C
[4] https://www.theengineer.co.uk/organ-on-a-chip-wyss-tel-aviv-university/
[5] https://bit.ly/2RVykOV

Image credits: Yonathan Tzhor, Tel Aviv University & Wyss institute, Harvard University

 

Eleanor Garth
Deputy Editor Now a science and medicine journalist, Eleanor worked as a consultant for university spin-out companies and provided research support at Imperial College London and various London hospitals in a former life.
Rejuvant

Most popular

New NAD+ boosting longevity supplement hits the market

Elevant Prime dietary supplement contains a “high purity” form of NMN that has completed safety and toxicology testing. New York based health and wellness brand...

David Sinclair to co-chair $200 million biotech SPAC

Christian Angermayer's Frontier Acquisition Corp. holds significant longevity interest with David Sinclair and Peter Attia as Co-Chairs of the Board. Frontier Acquisition Corporation, a special...

JUVICELL sets sights on lifespan and healthspan

Ten ingredients, one capsule. JUVICELL is on a mission to deliver an all-in-one longevity supplement. Far from just supplementing their diet to ensure an adequate...

Is nicotinamide riboside a safe and effective way to combat aging?

ChromaDex executive highlights the importance of clinical studies to prove the benefits of NAD+ boosting compound. ChromaDex is the company behind the popular healthy aging...
Supplement report

Related articles

Paving the way to future organ factories

Extracellular matrix obtained by controlled decellularisation is used to reconstruct the liver with human-like characteristics, paving the way for transplantable livers. Researchers at the Human...

The placenta: a limitless source of stem cells?

Part 1 of our exclusive interview with Celularity founder Dr Robert Hariri covers the discovery of placental pluripotent stem cells and the journey towards...

Insulin – predictor of longevity

Body weight stands for far more than simple aesthetics – it is key for longevity. From a single cell to a fully functioning human adult,...

Juvenescence debuts ketosis longevity supplement drink

Biotech Juvenescence's new product Metabolic Switch is a drink that supports healthy aging and a healthy metabolism by generating a state of ketosis. It's been...

Targeting neurodegeneration with $82m Series A

Alchemab raises £60 million to advance novel platform for identifying disease-modifying antibody therapeutics for neurodegeneration, cancer and more. UK-based biotech Alchemab Therapeutics has secured a...
Supps report ad middle