Stress makes life’s clock tick faster – and how to slow it down

Latest articles

“World’s first” cultural-matching app for care sector launches

Care receivers can be paired with carer based on religious understanding and culture thanks to AI tech developed during pandemic. A graduate has created what...

Biotech LyGenesis expands its liver regeneration tech

A new peer-reviewed paper demonstrates the success of using fat-associated lymphoid clusters as expandable niches for ectopic liver regeneration. LyGenesis, a clinical-stage biotech developing cell...

NURO embarks on funding round for neurotech communication system

World’s first multimodal neurotech operating system from NURO allows you to communicate using just your brain. DISCLOSURE: Longevity.Technology (a brand of First Longevity Limited) has...

It’s time to reboot longevity and healthy aging

Dr Michael Roizen calls for fundamental societal changes to ensure the benefits of longevity and healthy aging are realised. Later this year, best-selling author Michael...

Most read

New supplement slows aging and promotes weight loss

Sugar-proof your way to a longer life. Reducing AGEs to slow aging and increase weight loss – how one supplement is fighting the war...

An antiaging supplement that also reduces appetite?

One for the AGEs: Juvify signs IP licensing deal with Buck Institute for GLYLO antiaging supplement that aims to reduce glycation. A researcher at the...

Resveratrol – the small molecule with big antiaging ideas

When it comes to antiaging molecules, we can learn a thing or two from plants. As so often in natural world, plants have a few...

Editor's picks

“World’s first” cultural-matching app for care sector launches

Care receivers can be paired with carer based on religious understanding and culture thanks to AI tech developed during pandemic. A graduate has created what...

Biotech LyGenesis expands its liver regeneration tech

A new peer-reviewed paper demonstrates the success of using fat-associated lymphoid clusters as expandable niches for ectopic liver regeneration. LyGenesis, a clinical-stage biotech developing cell...

NURO embarks on funding round for neurotech communication system

World’s first multimodal neurotech operating system from NURO allows you to communicate using just your brain. DISCLOSURE: Longevity.Technology (a brand of First Longevity Limited) has...

Click the globe for translations.

Chronic stress accelerates the body’s epigenetic clock, but emotional regulation and self-control can slow that process down.

In new research, a team from Yale has used the DNA methylation GrimAge clock to investigate the extent to which chronic stress accelerates our biological clocks and whether there are ways to slow aging down and extend both lifespan and healthspan.

Longevity.Technology: Nutrition, genetics, lifestyle and diseases all affect biological age, and research has refined ways to pin-point biomarkers – measurable biological characteristics – that can reveal the secret of a person biological age, rather than just what number their last birthday celebrated. Psychomarkers, psychological markers, can also measure aging. One of the most promising biomarkers identified lies in epigenetics, the study of phenotypic changes to gene expression.

According to this new research, which has been published in the journal Translational Psychiatry, stress can make life’s clock tick faster – but the news isn’t all bad, as individuals can use emotion regulation and self-control to help manage the effects.

Rajita Sinha, the Foundations Fund Professor of Psychiatry at Yale, a professor of neuroscience and professor at the Yale Child Study Center, and one of the authors of the study, is a stress expert, having spend many years studying stress and the numerous harmful effects it can have on our health, both mental and physical.

Prolonged stress has been shown to increase the risk of heart disease, addiction, mood disorders and post-traumatic stress disorder, as well as influencing metabolism and accelerating obesity-related disorders such as diabetes. Stress also causes trouble for our wellbeing, hampering our ability to regulate our emotions and reducing our ability to think clearly.

A Yale team led by Sinha and Zachary Harvanek, a resident in the Yale Department of Psychiatry, wanted to explore whether stress can accelerate aging in a population that is relatively young and in good health.

The researchers studied the blood of 444 people, aged 19 to 50, evaluating the samples to determine age-related chemical changes captured by GrimAge, as well as other markers of health. A questionnaire answered by the participants shed light on their stress levels as well as their psychological resilience.

After demographic and behavioural factors such as smoking, body mass index, race and income had been accounted for, the researchers found that those who scored high on measures related to chronic stress also exhibited accelerated aging markers and physiological changes such as increased insulin resistance [1].

However, stress didn’t affect all the subjects in the same way; subjects with high scores for two psychological resilience measures – emotion regulation and self-control – demonstrated more resilience to the effects of stress on aging and insulin resistance, respectively.

“These results support the popular notion that stress makes us age faster,” Harvanek said, “but they also suggest a promising way to possibly minimize these adverse consequences of stress through strengthening emotion regulation and self-control [2].”

It would seem as if the more psychologically resilient the subject, the higher the likelihood that they could expect to live a longer and healthier life, explained Harvanek.

“We all like to feel like we have some agency over our fate,” Sinha added. “So it is a cool thing to reinforce in people’s minds that we should make an investment in our psychological health [2].”

[1] https://www.nature.com/articles/s41398-021-01735-7
[2] https://news.yale.edu/2021/12/06/stress-makes-lifes-clock-tick-faster-chilling-out-slows-it-down

 

Eleanor Garth
Deputy Editor Now a science and medicine journalist, Eleanor worked as a consultant for university spin-out companies and provided research support at Imperial College London and various London hospitals in a former life.

Most popular

New supplement slows aging and promotes weight loss

Sugar-proof your way to a longer life. Reducing AGEs to slow aging and increase weight loss – how one supplement is fighting the war...

An antiaging supplement that also reduces appetite?

One for the AGEs: Juvify signs IP licensing deal with Buck Institute for GLYLO antiaging supplement that aims to reduce glycation. A researcher at the...

Resveratrol – the small molecule with big antiaging ideas

When it comes to antiaging molecules, we can learn a thing or two from plants. As so often in natural world, plants have a few...

Sugar-proof your health with the GLYLO weight loss and antiaging supplement

Move your New Year's resolution up a gear with GLYLO, a double-action supplement that can increase weight loss while also slowing aging. Choosing an effective...

Related articles

Abbott launches Lingo longevity wearable with continuous ketone tracking

Abbott pushes the envelope of biowearables as it announces its new tech for tracking ketones biomarkers. Abbott, the company behind the Freestyle Libre continuous glucose...

Defining the new field of longevity medicine

A consortium of scientists and medical doctors have collaborated to define the new field of longevity medicine. Today, a group of scientists and medical doctors...

A brain fitbit that can spot Alzheimer’s with up to 94% accuracy

Altoida raising new financing for augmented reality cognitive assessment platform that dramatically improves early detection of Alzheimer’s and other neurodegenerative diseases. Earlier this year, AR-powered...

Immune systems and internal clocks in aging

We are an aging population – but what is happening internally as the years pass us by? We continue our overview of the Longevity Forum’s...

How can you measure and increase your Klotho protein levels?

Unlocking the secrets of the Klotho protein could extend your lifespan and healthspan – but first you have to measure your Klotho levels. The Klotho...

    Subscribe to our newsletter