The Sheekey Science Show – Sirtuins and SIRT6

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The longevity sirtuin – here’s what you need to know about SIRT6.

Sirtuins are highly-conserved proteins that are involved in a variety of important cellular processes such as DNA repair, metabolism and circadian rhythms.

Sheekey Science

The mammalian sirtuins (SIRT1-7) are a family of proteins that carry out NAD+-dependent protein deacylation and mono-ADP-ribosylation. These modifications on proteins can influence their stability, localisation within a cell and activity.

Sheekey Science

In the late 90s interest in sirtuins bloomed as it was found yeast lived 30% longer when they had an additional copy of a yeast sirtuin, Sir2. Similar studies have now been performed in mice, but whilst overexpression of SIRT1 in mice does not result in lifespan extension, overexpression of SIRT6 does.

Sheekey Science

This has led to SIRT6 being referred to as the longevity sirtuin. However, there seems to be some sex- and mouse strain-dependent differences.

Sheekey Science

So, in the remainder of the video, we will discuss what you need to know about SIRT6 including its proposed cellular activities, its association with longevity and how SIRT6 activation using allosteric activators could have future therapeutic potential.

Watch more Sheekey Science videos here.

Image credit: Windows / Unsplash
Phil Newman
Editor-in-Chief Phil is Editor-in-Chief Longevity.Technology and founder of First Longevity which brings together international investors and Longevity start-ups.

In his career, Phil has held c-level management positions; applying his marketing and business development expertise into these tech sectors: Longevity; IoT; AI; Medical Devices; Biopharma; 3D Manufacturing; Smartgrid and Sustainability.

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