MitoQ

Turn Bio announce worldwide IP for mRNA tech

Latest articles

A better model organism for testing antiaging drugs?

Harvard researcher proposes the Daphnia water flea as an alternative to worms for building a scalable platform for antiaging drugs research. In many ponds and...

Small is mighty when it comes to mitochondria supplements

Optimise, energise, revitalise – MitoQ is on a mission to supplement your mitochondrial health. Coenzyme Q10 – or CoQ10 – is made naturally in the...

What the aging field needs

Changing the narrative – Celine Halioua reveals why the aging field needs to be taught some new tricks. Celine Halioua is the Founder and CEO...

Insilico Medicine gets $255m boost for AI-powered R&D

Insilico closes $255 million to progress into human clinical trials and develop novel targets and also announces Teva Pharm collaboration. Insilico Medicine, a company driving...

Most read

New NAD+ boosting longevity supplement hits the market

Elevant Prime dietary supplement contains a “high purity” form of NMN that has completed safety and toxicology testing. New York based health and wellness brand...

David Sinclair to co-chair $200 million biotech SPAC

Christian Angermayer's Frontier Acquisition Corp. holds significant longevity interest with David Sinclair and Peter Attia as Co-Chairs of the Board. Frontier Acquisition Corporation, a special...

Tree of Longevity – understanding how supplements work

Pathways? Hallmarks? Biomarkers? Understanding the longevity supplements lingo can help you make better choices for your healthspan. Longevity supplements differ from other 'generic supplements' as...
fundraising

Editor's picks

A better model organism for testing antiaging drugs?

Harvard researcher proposes the Daphnia water flea as an alternative to worms for building a scalable platform for antiaging drugs research. In many ponds and...

Small is mighty when it comes to mitochondria supplements

Optimise, energise, revitalise – MitoQ is on a mission to supplement your mitochondrial health. Coenzyme Q10 – or CoQ10 – is made naturally in the...

What the aging field needs

Changing the narrative – Celine Halioua reveals why the aging field needs to be taught some new tricks. Celine Halioua is the Founder and CEO...
MitoQ

Click the globe for translations.

Turn Biotechnologies licenses technology to unwind the effects of aging at a cellular level, with patents pending globally protect the company’s mRNA-driven platform.

Turn Biotechnologies, a company developing medicines for currently untreatable age-related conditions, has today announced that it has acquired the global rights for new technology that reprograms cells to undo many of the effects of aging. The company licensed its epigenetic reprogramming of age (ERA™) technology from Stanford University, where it was developed by three researchers who founded Turn.

Longevity.Technology: Turn Bio claim that theirs is the first technology to maintain cellular identity while restoring specific cells’ youthful functionality, to trigger the body’s ability to fight age-related diseases. The company also announced that it has also filed for patents to protect its technology in major-market nations on six continents; this will buoy interest in Turn Bio further after their success with Yamanaka factors last year.

“ERA technology is an extremely powerful platform and can be used to treat a variety of diseases throughout the body,” said Anja Krammer, Turn CEO. “The steps we have taken ensure that the fruits of our research can benefit millions of people around the world.”

A study published last March in the journal “Nature Communications” highlighted the promise of Turn’s ERA technology to treat age-related health conditions. The study found that old human cells can be induced into a more youthful and vigorous state when they are exposed to a rejuvenating treatment that triggers the limited expression of a group of proteins known as Yamanaka or transcription factors, which are important to embryonic development [1].

 


 

“The ability to precisely control a cell’s rejuvenation means we will be able to turn back the clock on cellular vitality, effectively restoring cells’ ability to heal or regenerate damaged tissue.”

 


 

ERA uses messenger RNA (mRNA) to deliver these transcription factors to the cells’ epigenome, which controls cellular activity. As the epigenome ages, it prevents a cell from functioning optimally. The transcription factors – which can be delivered in a variety of combinations to target different cells – effectively revitalise the epigenome, restoring the cells’ ability to behave more youthfully.

“The ability to precisely control a cell’s rejuvenation means we will be able to turn back the clock on cellular vitality, effectively restoring cells’ ability to heal or regenerate damaged tissue,” said Jay Sarkar, Turn’s chief technology officer and a company founder who helped to develop the ERA technology. “Our research offers promise to people suffering from age-related diseases for which there are currently no cures.”

Turn’s technology uses mRNA to produce instructions that induce cells to treat or prevent disease. Messenger RNA made possible the speedy development of two recently announced COVID-19 vaccines. An advantage of mRNA is that it is safe because it never enters the cell nucleus where DNA is kept and the cell effectively gets rid of the mRNA after it has used the instructions carried by it.

Just as it led to the lightning-fast development of COVID-19 vaccines, use of mRNA heralds a revolution in the development of therapeutics by making that development safer, faster, more efficient and tuneable to patient need.

Turn is currently completing pre-clinical research on tailored therapies targeting indications in dermatology, osteoarthritis and cartilage damage, ophthalmology and musculature.

[1] https://www.nature.com/articles/s41467-020-15174-3

Image courtesy of Turn Biotechnologies
Eleanor Garth
Deputy Editor Now a science and medicine journalist, Eleanor worked as a consultant for university spin-out companies and provided research support at Imperial College London and various London hospitals in a former life.
MitoQ

Most popular

New NAD+ boosting longevity supplement hits the market

Elevant Prime dietary supplement contains a “high purity” form of NMN that has completed safety and toxicology testing. New York based health and wellness brand...

David Sinclair to co-chair $200 million biotech SPAC

Christian Angermayer's Frontier Acquisition Corp. holds significant longevity interest with David Sinclair and Peter Attia as Co-Chairs of the Board. Frontier Acquisition Corporation, a special...

Tree of Longevity – understanding how supplements work

Pathways? Hallmarks? Biomarkers? Understanding the longevity supplements lingo can help you make better choices for your healthspan. Longevity supplements differ from other 'generic supplements' as...

Spermidine: the mind-enhancing supplement

Scientists are finding that a high intake of dietary spermidine could slow down (or reverse) the brain aging process. Memory loss and slower brain function...
fundraising

Related articles

A better model organism for testing antiaging drugs?

Harvard researcher proposes the Daphnia water flea as an alternative to worms for building a scalable platform for antiaging drugs research. In many ponds and...

Longevity focused crypto platform to launch token auction

Lead researcher behind VitaDAO’s first project reveals more about his work and why crypto provides an exciting new funding option for longevity scientists. Later this...

Improving speed and accuracy in Alzheimer’s patients

Phase 2a study of patients with Alzheimer's or Parkinson's finds that ANVS401 treatment leads to significant improvement in speed and accuracy. Annovis Bio Inc, a...

Brinter accelerates 3D bioprinting with €1.2m seed fund

Modular multi-material 3D bioprinting solution hopes to develop cost-effective answer to global need for kidney transplants. Turku-based bioprinting start-up Brinter has today announced the successful closure...

Occuity – shining a light on health and longevity

Forget windows to the soul, Occuity's non-invasive smart diagnostic tech provides a window to health and wellness. DISCLOSURE: Longevity.Technology (a brand of First Longevity Limited)...
MitoQ